She sensed his anxiety and uneasiness as him having sight issues. But today, after he ate dinner and drank water, it all came back up. After about 2.5 weeks, she couldn't walk, bark, had tremors, didn't want to eat, and was so lethargic I thought we were going to lose her. They did an ultrasound (2 of them), X-rays, blood test, gave fluids, did another ultrasound (looking for a master fluid that keeps popping up and going away between her stomach cavity & spinal cord. Side-Effects Of Simparica Trio Tablets There are some mild side effects like Vomiting Diarrhea Loss of appetite Dog owners should be aware that these tablets are not suitable for all dogs. Copyright 2023 Meredith Corporation. Simparica is available by prescription only, so discuss any history your dog has of seizure disorders with your veterinarian when determining the best flea and tick treatment for your pet. Shes now in the Er. March 2016 saw the addition of Simparica, yet another so-called Isoxazoline flea and tick "remedy" and already several dogs have been adversely affected by this new drug. Initially I noticed minor tremors and twitching when he slept or was just relaxing. He is very friendly with other people and pets and never had an issue in that regard. If you give your dog or cat the flea and tick preventatives Bravecto, Nexgard, Simparica, or Credelio, the FDA wants you to be aware that these medications may cause neurological issues like stumbling, seizures, and twitching in your pet.Though these products are FDA-approved, data received by the agency as part of its post-marketing activities showed the potential for adverse neurological . If my dog dies, which does not look too good right now for him, I will stop at nothing to make the company's life miserable. However, these adverse effects are rarely observed in pets and overall the product is proven to be suitable for all dogs without the occurrence of any side effects. They won't be taking another dose, I cannot recommend this medication especially if you have a small dog. How long did the itching last with your pet. There is NO other explanation for this rapid decline and the only change has been THIS drug. My 11 year old terrier mix has been weak, uncoordinated and pacing up and down the hallway most of the day, sometimes stopping and staring at the wall. Other specific monitoring or routine testing while your pet is on this medication may be recommended by your veterinarian depending on your pet's individual needs. Has anyone experienced cardiac issues while under anesthesia on this medication? Now it is March, on Tuesday I gave him his de-wormer and Wednesday he had a seizure. Our new vet has recommended Simperica, but I wont be giving it to my Collie. Could this be caused by the med? This Tuesday the 17th I had given my dog simparica trio for 27lbs dose. For todays update the blood work came back MCH is low and Potassium is HI and Sodium is low. Thank you for giving information on what happened to your dog. After 9 days he began vomitting, even water, and mouth chattering like he was scared. He protected our livestock from coyotes for many years and I took good care of him. He is back to his old self now but we will never give him this medication again. The older of the 2 Poodles seemed to do fine but my younger Poodle who was about 3 years old was definitely affected and we had a difficult time even getting him to eat for at least 2 weeks. It has been one week and she has been acting very anxious since. The vet told me to switch to Simparica trio after they stopped seeking revolution which he had been on for many years. The FDA has issued a warning about the potential for neurological side effects associated with isoxazoline class drugs, including Simparica Trio. OMG - I am so mad at myself for not doing more research. I gave him this medication last Thursday. I do believe it caused her blindness. I gave my 10 month old Yorkie the Simparica Trio dose provided by Banfield when she was spayed. We trusted our Vet when he recommended this over Revolution topical anti-tic/flea medication. I feel so dumb for taking him off of something that we had no problems with and it worked fine, just to try something new that he didn't need. This can help with feelings of anxiety, stress, and fear." The term off-label or extra-label use means that a medication is used in a way or in a particular species that is not specified on the medication label. I suppose with any drug, during trials, there will be some who have side effects ranging from negligible to life threatening. My dog is experiencing these same symptoms and had his first accident in yearsss in the house and is drinking water excessively. How did your baby do please? I'm more concerned about fleas and heartworms and Trifexis is just fine for that. The revolutionary chewable tablet - Simparica is highly effective in eliminating fleas and various types of ticks. Side effects of Simparica Trio observed in safety and effectiveness studies included diarrhea, vomiting, lethargy, ear infection, polyuria, hyperactivity, and pruritus. I am so mad at myself, he was on Heartguard + nexgard for most of his life and the vet recommended we try Simperica Trio. And for those who have lost their fur babies I am so sorry for your lost. All said, we are over $8K into vet bills and growing, Given that he had no noted medical issues prior, his vet and the urgent care vet both feel is was likely the Simparico. This medication must really be strong to do Flea tic and heart worm etc. Currently we are monitoring him closely-hes never been sick. Pyrantel pamoate is a nematocide (kills some worms) belonging to the tetrahydropyrimidine class. Simparica Trio is just one of many parasite prevention products on the market for dogs. I am convinced this medicine is HORRIBLE and is causing this. There is a possibility it isn't the cause, but it is the only reason I can find and it aligns with the stories of others. I am terrified--wish I would of seen this sooner. With Entyce she is getting her appetite back and seems a little better. I had to put him laundry room for the night (no Carpet). Simparica and Simparica Trio are available by prescription only. Lost his appetite & was low on energy all day yesterday, slept most of the day - which is very unusual for him. This morning was the first morning he left water in his bowl. He is a 6 month old Bloodhound so they are always hyper. This neurotoxin destroys fleas, ticks, and other insects for 35 days after your dog takes the medicine. I hate giving her these drugs in the first place but am always convinced it is the right thing to do. Will not eat or drink. Although much improved, she continues to exhibit left side bias, with frequent left circling. Can you tell me if your dog is back to normal now?!?! I will never give him this drug again. Don't risk the well-being of your beloved dog just because something is more convenient. Anyway, he prescribed him pain relief for 7 days. Any suggestion? Glad i held off on the free sample i was given! I will never give another dose to him! My vet reached out to Simparica Vet Rep, who, I was told, stated they were unaware of this neurological side-effect? The other has had diarrhea every since 6 hours after the pill. It is the flea and tick component that is the problem. I originally wanted to get Nexgard, but for some odd reason, when I had went to my vet to pick it up, instead they gave me this. Not drinking any water but drooling and swallowing all the time. He had it once before with no issues. Again he has diarrhea and this month he seems agitated or nervous. If she recovers, cause is the Simparica. She's pacing and wants to eat grass. After reading theses comments I started looking into SIMPARICA TRIO. In a third field safety and effectiveness study, Simparica TRIO was administered to 120 dogs with roundworms. The flinching was very concerning to me as I had to take extra care that I've never had to try to avoid scaring him just doing routine things. He also lashes at me with his teeth. I gave the 1st one to my dog, 1st of this month. Just be aware that no oral tick medicine is safe, all are from the same class of drugs. He has trouble raising his leg to urinate. His vet doesn't think it has anything to do with the Trifexis but I cannot help but think it IS because he was just fine the day before I gave it to him! I went to zoetis and Expressed my views and they said the FDA report meant nothing and it was in America. There is a petition in Australia to have this drug banned through change.org, which I've signed. As I said, the first was a week after taking it, then the 2nd and third seizure happened at day 29. My little Billy Boy had his first visit to the vet and they gave him Simparica Trio. My dog is a 13-15 yr old rescue shitzu mix. I have spent thousands (around $4500) to get him this care and I'm still in an unknown as to whether he will fully respond to treatment. My 10 year old Standard Poodle had one dose of Simparica and had seizures two weeks later, which was yesterday. Poor baby has had vomiting and diarrhoea ever since. It will eliminate infestations of deer or black-legged ticks, lone star ticks, Gulf Coast ticks, American dog ticks, and brown dog ticks. The vet suggested Simparico trio . We rushed him to the emergency vet and they put him on keppra to stop the seizures. Our baby isnt the same at all since his one and only dose of Simparica. Product Description. In isolated cases, however, dogs displayed more serious reactions such as tremors, muscle twitching, and seizures. I also lost my dog due to simparia Trio. I was giving my 70 lb golden doodle Trifexus, for nearly 2 years until suddenly he refused to eat it. I'm using milk thistle and broccoli sprout powder, and going forward I'm going to use HWF Clean Heart for heartworm prevention. His motor skills have been affected and hes been losing weight even though he eats heartily. I just gave Bentlee my Akita Simparica Trio on the 9th. What are the risks associated with Simparica? Ticks are horrible here in Maine. Sorry for the late replywe took our boy to the ER and after 2 days on fluids and a shot of Percorton, he was diagnosed with Addison's Disease. Now we are out thousands of dollars when every event has been triggered by Simparica Trio. Hi Laura, How is you pup doing one after getting off simparica? He is just laying in his crate . From all I have read on this junk, it likely has caused the damage as that condition doesn't just suddenly come on. I guarantee he will not take this trash again. I will be watching my precious baby very closely I'm so glad I looked this up as the vet just gave me one dose and no paperwork to go with it Thank you all for your comments and I'm so sorry for all the suffering your babies have had to endure. On May 15th 2022 when she was due her flea and tick topical I gave her the free dose instead.Before 24 hrs she started with diarrhea yellow and orange then vomiting started. Hello! He returned to vet, rec'd an allergy injection, first in his life, plus Penicillin x 10 days. Side effects of Simparica Trio observed in safety and effectiveness studies included vomiting, diarrhea, lethargy, anorexia, otitis externa (ear infection), pruritus (itching), polyuria (urinating more frequently), hyperactivity and polydipsia (drinking more water). For the treatment and control of tick infestations with Amblyomma americanum (lone star tick) and Ixodes scapularis . And how do we get the word out to everyone? Almost $4k in medical labs, hospital, ultrasound etc no answers. She hasn't had any of the diarrhea or eating issues, but has had one of her eyes that gets red and the inner eyelid partially covers her pupil. I will be discontinuing the medication. So your dog got better? Does anybody know how long this will last? Thank you all for speaking out on Simparica Trio that Bandfield Hospital pushed on our Toy Poodle. So the next day was Saturday , me & my husband got up early . I gave my six-year-old dog SIM perica because the combo guard was on back order. How do I get this out of his system and what are you using instead? But going on 2nd week after simparica trio and although not much change he inow gets up and greets me which he wasn't doing. He has never acted like he was in pain. My vet recommended this for my puppy, he is now lethargic, has blood in stool, and can hardly stay awake. Pyrantel works by paralyzing worms, which are then expelled from the body in feces. He drank not crazy about dog food . - she's had several episodes since then. My one year old has severe diarrhea and is very agitated and anxious. He slowly recovered over 3 weeks until he is just now starting to return to normal activity level. How can it not be the Simparica that did this to my baby when nothing else changed. Call the FDA. What are the side effects of simparica trio for dogs? Next she developed severe tremors. We have never had issues with him peeing in the house - EVER, and he peed in my office. Tick titer came back a light positive which lab said was specifically false due to the recent lyme x2 booster i was scared in to giving. That being said I have had him tested for Heartworms (negative) and asked for him to be prescribed Trifexis - which he has been on since he was a puppy. Get the dog moms and dads in your life something unique this year. Meaning he is suppose to get it today. Other adverse reactions like lethargy, anorexia, itching, and increased thirst are possible but not very likely. So if your dog actually has meningitis then that wouldn't be related to having given him Simparico but a separate matter altogether. Not Trio because of all the seizure horror stories. Supply ran out, switched to Simperica. KingsGuard2603 2 yr. ago. Today is day three and she is a little better, with fewer episodes of tremor and more often able to walk without falling. I am both incredibly sad and angry. I just wish I could find a vet who honestly loves my animals as much as I do. I recently switched my 3.5 year old German Shepard to simparica and about 2 weeks after his first dose he had two seizures in one night and has NEVER had them before. The company's thinking must be the profits outweigh the loses from any lawsuits lost its important to note that the law treats animals as property and the fix value of a dog is quite small and limited. About 11 months ago our vet recommended Simparica Trio. Gave my 3 month old, 3 pound shih tzu simparica on Sunday night. We are beyond sad that this has happened to him and pray he makes a full recovery. His immune system is destroying his red blood cells . We have spent well over $5000.00 and upset about all the horror stories we are now hearing. He has been getting groomed since he was 3 months old but we've noticed that he has been getting more anxious with time. I won't be letting this go and I'll be actively pursuing recourse from the manufacturer and vet in any way I can. Simparica trio is a de-worming medication. Ekko then started having seizures in May,June and July. The following day he would not even drink water. Thanks to its innovative formula, the treatment continues to work for 35 days, providing long-lasting relief from parasites and the diseases they carry. The vet has reported it (at least she too thinks it came from the drug) and a chiropractor checked her for the possiblility of slipped disc etc and said it's not that. Stopped meds and he has had 3 more seizures since. Simparica, Nexgard, Bravecto and Credelio are part of a group called Isoxazoline drugs. I gave our boy, Yogi his first dose of Simparica TRIO on 11/17/2020. After doing more research on their monthly medication, I will no longer use Simparica Trio nor ever recommend it. lola weighs about 9lbs. Each month he got sicker and sicker. We will have blood work and results this evening. He is sometimes picky with his food, so I mixed in some green beans, etc but he stopped eating anything and had bright orange diarrhea by the 31st. You don't think I'm going to continue with this poison. We wont be using this medicine ever again! I've spoken to emergency vets and they say they are booked solid and that I need to just monitor her through the night. Consulting vet and will not give Simparica ever again. I am so worried after reading these comments. I am also very worried about him. May not be from this med but too strange to at least not think about it. I found a warning from the FDA about the potential for neurologic adverse events in dogs and cats when treated with drugs that are in the isoxazoline class. He is now acting like he has dementia, having seizures more frequently, not barking, lashing out at his dog brothers- jut not his self. This should be taken off the market-it's just a BIG pharmaceutical moneymaker at the expense of animals and their unsuspecting owners. Simparica Trio contains sarolaner, a member of the isoxazoline class, which has been associated with neurologic adverse reactions including tremors, ataxia, and seizures in dogs with or without a history of neurologic disorders. Also vets needs to tell the truth!!! I will keep a close eye on him and hopefully nothing else come about, we will NEVER take this medication again! My dog was HEALTHY and HAPPY prior to giving him this drug and literally days later he is struggling to recover. I have always used topical tx. . The third ingredient in Simparica Trio is pyrantel. Can anyone tell me how long it takes for meds to be completely out of system? No appetite, not like Charlie. So bad that the FDA made them put a huge warning now on the package. Even with what she has been through we have to wait until Dec 1st to see the Neurologist as there is only one in the State of Maine. GAGA-gated channels help to calm nerve transmissions, which sarolaner alters, creating an influx of nerve transmissions. She has been treated by this clinic since birth. I brought him to the vet and they keep trying to say excessive water drinking isnt a side effect but its the only thing that is different that Ive given my pup. Fortunately for conscientious dog moms and dads, Simparica offers a once-a-month chewable treatment that is FDA-approved and safe for Fido, taking the guesswork out of fighting fleas and ticks. The more we complain the more chance we have of saving other dogs. Not wanting to play, shivering, and drinking excessively. I know Dukes problems were from this medicine, and it upsets me that my vet told me that this medicine was safe! Moxidectin was first approved by the FDA in 1997 for the prevention of heartworm disease in dogs. Best case scenario, he is able to come home, but we aren't there yet. This medication should be banned and the company held responsible. What Are Potential Simparica Trio Side Effects in Dogs? She nearly died. It could be something else that had caused her all the pain she went through but I surely will not give my puppy Simparica anymore and I hope she is alright. Sarolaner is effective against the following tick species: Moxidectin is an antiparasitic drug in the macrocyclic lactone class. After reading all your entries, i'm thrilled i chose to take her off of it. Never again are my dogs getting oral medication for fleas & ticks. Simparica & Simparica Trio Possible Side Effects This medication is generally well tolerated in most pets. He started having skin issues that the vet said were allergic reactions probably due to environmental things. My last one lived to almost 15yrs old and I truly believe it was because I had him on Springtime Garlic tabs. If this is a long term issue, I doubt they would be willing to cover all visits in the future. I gave my black lab mix Simparica for the 1st time on 4/1. Gave my dog Charlie Simparica yesterday now he is shaking and panting really bad. They can also have major side effects. ALL oral tick meds are in the same class of drugs, so cannot give anything with that in it. I definitely will not poison her with this garbage anymore. But now I'm almost convinced that they could have been seizures, and I just pray that they weren't, and pray that he doesn't have to experience anymore troubles. I'm also wondering if his anxiety is related as well. Was prescribed Simparica Trio for my Catahula dog with no medical issues. I am going to try stopping the medication for a month to see if things improve. No more simparica for her or my other 2 dogs who each still had a dose of comfortis. I have every intention of calling and filing a complaint. Hopefully there are many other dogs that are unaffected, and just aren't written about here. Im just hoping my sweet girl is going to be ok. My English Springer Spaniel(Sadie) received her first dose of Simparica Trio at 12 weeks old, with no noticeable side effects. She is only 6 and was so full of life and energy. She would constantly twirl in left circles. (Ours never did, she died 4 months later.) The only change I could think of he started taking Simparica about 4 months ago. Seems like it was directly related to the medication. However, some dog parents prefer to use separate products. Simparica is only safe for dogs. I am so mad at myself for letting the vet talk me into this. Both of them aren't eating like they were. And urinating more often as a result. No problem eating. They keep telling me that she would have been sick from the first pill, not just the 2nd. I just wanted to get another opinion before we move forward. 2-6 days in vomiting here and there. All other pets in the home must also be treated with a flea control product for a minimum of 30 days prior to the report. I would notice he gets super tired walking and would go limp in my arms. He is 5 months old. I too would like to know how long this symptom lasted in other dogs who experienced the same issue. The next day Bellas stools were quite soft but still had some structure. We did skin scrape and they kept saying allergies. I hope the best for you and dog, I know its a tough time. Serious side effects are rare, but you should still monitor your dog after administering Trifexis and report any . Simparica Trio is a veterinary medicine used to treat dogs with flea or tick infestations and roundworm or hookworm infections in the gut. About 2 weeks later he had tremors, drooling, lethargic, uncoordinated, vomiting and was touch and go for a couple days. Vet took blood yesterday should get results today. She won't drink E walk or anything The doctor seemed to push this drug on me because the kombi guard was on back order. I wish I would have seen this conversation before giving my 8 year old Labrador Retriever his first dose of Simparica Trio on Wednesday March 31st! only 7 yrs old and I still considered a puppy b/c of how active he was, we are on 8 days now of the lethargic not eating, goopy eyes - Dr says he has hyernaited disc but I have yet to see the xrays to confirm - blood work came back normail. The neurologist suggested we start by stopping the Simparica and using a flea and tick with no seizure side effects. I am a physical therapist, and acquired Sadie to serve as a Therapy Dog in our clinic. He already has canine dementia on and off. Advised her to put a big note on our account that she is never to have this again. My 12 yr-old Chihuahua mix is losing his hair right above his nose. This crap is poison! I honestly think she had a reaction to the medication. Simparica Trio contains three active ingredients . I give my dogs Simparica at the beginning of each month. By overloading chloride into these worms, it affects the electrical activity within their nervous system, causing muscle paralysis and death. Im so angry at these drug companies and vets for selling this crap. I have had German Shepherds for 40 yrs. HELP!! Your veterinarian is the best source of information and will help you choose the right product for your dog and your budget. Seizures are going on two hours.. She is scared of her own shadow, walks into things at times, trips and stumbles, has become very timid, stares at the wall and has to have either me or my husband in sight at all times. Then he came too . Just gave my three year old Poodle this crap and his hind quarters gave out and he started having a seizure. 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