Hyperpigmentation causes skin to become darker or different in color due to an abnormally high amount of melanin or other pigments in the skin. Researchers have long studied green tea for its potential antioxidant and anti-inflammatory properties. Hyperpigmentation can be caused by: Birthmarks Age spots Acne scars Pregnancy (during which melasma, or tan, brown, or gray patches can appear on the face) Addison's disease, or a rare disorder which causes decreased function of the adrenal gland and dark patches of skin Certain drugs such as antibiotics and birth control pills Sun exposure Hyperpigmentation causes patches of skin to become darker than the surrounding skin. The response can vary from person to person. Certain medications, such as antimalarial drugs and tricyclic antidepressants, can cause hyperpigmentation. Pigment Cell Melanoma Res. Along with hormones, genes are responsible for regulating the melanin production process. Last updated on Mar 8, 2023. DermNet does not provide an online consultation service. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Here are the best online birth control delivery companies. Absent missed or irregular menstrual periods. Can antibiotics affect IUDs like Kyleena, Mirena, or Skyla? Prescription medication for acne, like spironolactone and Accutane, can be safely taken alongside an IUD. 2017 Dec 15. Lauren Krouse is a journalist especially interested in covering womens health, mental health, and social determinants of health. There are a number of home. Skyla. However, if Mirena is left in place during pregnancy, not only is the risk of having a miscarriage higher, but also the risk of preterm labour. Can diet help improve depression symptoms? If you notice melasma symptoms on your face or body, its a good idea to check with a dermatologist to confirm your symptoms. What will you do to reduce the pain. This type of hyperpigmentation is common during pregnancy. What causes drug-induced skin pigmentation? Melasma is a very common cause of skin pigmentation. Healthline Media does not provide medical advice, diagnosis, or treatment. Best for . nausea. WebMD does not provide medical advice, diagnosis or treatment. Our website services, content, and products are for informational purposes only. Science. Others affect your entire body. To prevent pregnancy, Mirena: Thickens mucus in the cervix to stop sperm from reaching or fertilizing an egg. IUD's like Mirena, Kyla & Liletta can cause an over-production of progesterone which can lead to an imbalance of hormones. This may indicate that the synthetic hormone in the Mirena IUD leads to a slight gain in weight. Daisy11 - I have also experienced sun spots and facial discoloration while on the mirena IUD. Her work appears in Women's Health, Prevention, and Self, among other publications. This forms the foundation of all treatments. Pelvic inflammatory disease (PID): Another serious side effect that can occur with the use of Mirena is pelvic inflammatory disease (PID). Data suggest that around 6.4% of people who use the Mirena IUD experience low mood or depression within 5 years. Catch her on Twitter. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment. Consider speaking with a health professional to see which IUD might be the best fit for your body. Oakley, A. Meanwhile, it is worth noting that IUDs do not protect a person from STIs. fatigue. Last medically reviewed on April 22, 2021, An intrauterine device, or IUD, is a small device that doctors place inside the uterus as a form of birth control. These issues are uncommon. 2023 Healthline Media LLC. A doctor can identify the type and cause of hyperpigmentation. Any shift in skin tone can be concerning or upsetting. After cleansing, apply a toner to open the pores and allow other products to fully absorb, she adds. Drug-induced abnormal pigmentation of skin. Examples include: The birth control thats least likely to be linked to melasma includes barrier methods and non-hormonal birth control options. However, many factors can influence weight gain, including age. 2018;19(9):2668. doi:10.3390/ijms19092668, Crawford NG, Kelly DE, Hansen MEB, et al. All rights reserved. Having the Mirena taken out will not reverse melasma. "Product Information. Melasma is a very common cause of skin pigmentation. If you are allergic to Mirena (52 MG) ( levonorgestrel (IUD)); any part of Mirena (52 MG) (levonorgestrel (IUD)); or any other drugs, foods, or substances. For one, theyre about 99 percent effective at preventing pregnancy. Genetics, skin damage, sun exposure, and hormones can impact your skin pigmentation and cause it to lighten, darken, or change in color. These may include progesterone (the Mirena), photosensitizing medications, thyroid dysfunction, stress, and dysbiosis. Check with your doctor immediately if any of the following side effects occur while taking levonorgestrel: More common The cause of hyperpigmentation depends on the type. Here are some tips: Cleanse your skin at least once per day. These products should not be used to lighten complexion. Palma L, Marques LT, Bujan J, Rodrigues LM. What happens during the insertion procedure? Our website is not intended to be a substitute for professional medical advice, diagnosis, or treatment. See additional information. I have always been freckled and I recently turned 31, so I had assumed that this was due to natural aging. However, these options have varying levels of effectiveness, and a person may find using a diaphragm, for example, less convenient. Paragard. headaches. These side effects occurred in 510% of participants in studies of the Mirena IUD: These unwanted effects occurred in fewer than 5% of study participants over a 5-year period: PID may be a more common complication in people with other risk factors for the disease. Anyone who has the Mirena IUD and experiences unwanted effects should contact a doctor for advice. Skin damage from acne, blisters, cuts, sun exposure, genetic factors, and autoimmune conditions are all possible causes for changes in melanin and, thus, skin pigmentation. The Mirena IUD releases the hormone levonorgestrel, a synthetic form of progesterone. When the epidermis is exposed to ultraviolet (UV) or infrared radiation from the sun, as well as hormones found in certain birth control options, the melanocytes react by producing more melanin. If the IUD does perforate the uterus, it no longer works to prevent pregnancy, so the person may need a different method of birth control. Theyre also supposed to make your periods. If youre experiencing a medical issue, please contact a healthcare professional or dial 911 immediately. Acne-prone types should opt for a gel-based cleanser. Board-certified dermatologist warns consumers about the dangers of skin bleaching to achieve a lighter complexion. Books about skin diseasesBooks about the skin It is used to treat heavy bleeding during monthly periods (menstruation). The mini-pill can be a good option for people who would like to continue using the pill, but would like to avoid the symptoms of melasma. These hormonal types can cause acne breakouts, explains Green. In these cases, patches of skin may turn gray. IUDs like Mirena, Kyla & Liletta can cause an over-production of progesterone which can lead to an imbalance of hormones. People can use creams containing glabridin on areas of hyperpigmentation. Can diet help improve depression symptoms? In very rare cases, people using the Mirena IUD experience: All of these are serious issues that require immediate medical attention. Learn about Mirena, Paragard, Skyla, Liletta, and Kyleena, how they differ, and which IUD may be right for you. Oral contraception is a safe, effective way to prevent pregnancy and relieve period pain. Try following a low-glycemic diet involving plenty of fresh vegetables and beans. Research notes that increasing how much water you drink everyday can positively impact the skin's overall health and appearance. However, there's very little scientific data on how common . This survey is being conducted by the WebMD marketing sciences department. For example, it may be more likely to develop in someone with a sexually transmitted infection (STI). This can cause dark spots or patches on the skin called age spots or sun spots. Skin Discoloration: Causes and Treatments, Hyperpigmentation Around the Mouth: Everything to Know. However, some people may prefer to remove it. Inside these special skin cells are organelles (or mini-organs of the cell) called melanosomes. Progestin, she says, can send your body in a frenzy, throwing off [its] hormonal balance.. This synthetic hormone can also prevent ovulation, though it does not always have this effect. Opt for light and loose clothing that protect your shoulders and chest when youre outside on sunny days. Drug-induced pigmentation is a form of abnormal skin pigmentation that is caused by drugs through several different mechanisms. Long-acting reversible contraception: Intrauterine device and implant. Treatment of drug-induced hyperpigmentation involves stopping the causative drug; the hyperpigmentation fades very slowly in some if not all cases. Some cosmetic procedures can also lighten areas of skin to reduce the appearance of hyperpigmentation. Cosmelan is a gold standard leave-on peel that has a high concentration of antioxidants and skin brightening actives that can used safely on all skin types especially skin types that have irregular pigmentation such as African American, hispanic, asian and mixed ethnicities. How Viagra became a new 'tool' for young men, Ankylosing Spondylitis Pain: Fact or Fiction, https://omr.bayer.ca/omr/online/veeva/Mirena_PIB.pdf, https://journals.lww.com/greenjournal/Abstract/2020/05001/Weight_Gain_Associated_With_LARC_Within_a_Racially.355.aspx, https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/021225s040lbl.pdf, https://www.ncbi.nlm.nih.gov/books/NBK557403/, https://link.springer.com/article/10.1007/s11920-019-1034-z, https://link.springer.com/article/10.1007/s13669-020-00295-9, https://www.plannedparenthood.org/learn/birth-control/iud/what-are-the-disadvantages-of-iuds. American Society for Dermatologic Surgery (ASDS). How Viagra became a new 'tool' for young men, Ankylosing Spondylitis Pain: Fact or Fiction, https://www.aad.org/news/dangers-skin-bleaching-to-achieve-lighter-complexion, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6826613/, https://www.msdmanuals.com/en-gb/professional/dermatologic-disorders/pigmentation-disorders/hyperpigmentation, https://escholarship.org/uc/item/3455571b, https://www.ncbi.nlm.nih.gov/pubmed/28139161, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5843359/, https://www.aad.org/media/news-releases/dermatologist-shines-light-on-natural-ingredients-used-in-new-topical-treatments-for-hyperpigmentation, https://www.aocd.org/page/Hyperpigmentation, https://www.aad.org/public/diseases/a-z/melasma-overview, https://dermnetnz.org/topics/postinflammatory-hyperpigmentation, https://www.dermnetnz.org/topics/pigmentation-disorders/, https://www.ncbi.nlm.nih.gov/books/NBK430862/, https://www.ijord.com/index.php/ijord/article/view/765, https://www.ncbi.nlm.nih.gov/books/NBK539693/, https://www.niddk.nih.gov/health-information/endocrine-diseases/adrenal-insufficiency-addisons-disease/symptoms-causes, https://pubmed.ncbi.nlm.nih.gov/33160435/. Although there are stories of IUDs clearing skin, there are also a number of anecdotes of the devices causing acne. This suggests, that in some cases, staying hydrated may help with some types of skin pigmentation. So the end result is a more even skin tone without as many irregularities. Learn how your body is affected by. What should I know regarding pregnancy, nursing and administering Mirena Intrauterine Device to children or the elderly? While any birth control brand that contains estrogen or progesterone can put you at risk for developing melasma, those with lower doses of hormones are found to be less likely to cause it. Doctors are unsure about what causes melasma, but a change in hormones can trigger it, for example, during pregnancy or when using birth control pills. We avoid using tertiary references. Melasma does not cause any other symptoms beyond the cosmetic discoloration. Some skin-lightening creams, such as steroids and hydroquinone cream, have been linked to: People should speak with a doctor before using skin-lightening products, as they may cause adverse effects. Paragard is a copper IUD, while hormonal types release varying amounts of a synthetic hormone called progestin. While a hormonal IUD may cause breakouts in one person, another may experience zero skin-related side effects. Drug-induced skin pigmentation can become cosmetically disfiguring. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. All rights reserved. The final step is skin-protecting sunscreen. Topical treatments will include ingredients that can lighten the skin, such as: Creams containing steroids and hydroquinone can take 36 months to affect the skin color. Read our, Post-Inflammatory Hyperpigmentation and Acne. You can learn more about how we ensure our content is accurate and current by reading our. Another laser I use is the Clear and Brilliant in the 1927 Permea setting combined with creams. Dont hesitate to reach out to a healthcare provider or therapist for more help. Post-inflammatory hyperpigmentation. Laser resurfacing. Learn more about the different birth control pill options. The studys finding does not necessarily prove that the IUD causes a person to gain weight. We examine what causes it and the potential treatment and prevention methods. Here, we reported one case of acute urticaria following Mirena implantation to increase the awareness of possible adverse side effects associated with Mirena. If not, over-the-counter and prescription creams could help restore your skin tone. Berlex Laboratories (2003): 2. "Product Information. More serious causes of hyperpigmentation include Addisons disease and hemochromatosis. People can apply aloe vera gel from the plant directly to the skin daily. When progestin the synthetic version of progesterone found in IUDs is released into the body, it can stimulate androgenic activity. Whats the Difference Between Vitiligo and Albinism? If a person notices other symptoms alongside hyperpigmentation, they should seek advice from a doctor. All rights reserved. If youre unable to stop your birth control or notice that your melasma sticks around once you do stop, there are still ways to treat and manage your symptoms. Kyleena. Select a condition to view a list of medication options. Trivedi M.K., et al. Always purchase products from a reputable source and follow the instructions on the pack. Best for all skin types: SkinMedica Lytera 2.0 Pigment Correcting Serum. The Mirena causes about 12 percent of women to grow one or more ovarian cysts, sometimes called enlarged follicles. Depending on the cause, you may benefit from therapies such as: If a patch of your skin or a mole changes in color, texture, or shape and does not fade, contact your healthcare provider to schedule an appointment. The Mirena IUD works in a similar way to other progesterone-only types of birth control, including: As a result, all of these contraceptives can cause similar side effects. Along with its needed effects, levonorgestrel (the active ingredient contained in Mirena) may cause some unwanted effects. The Mirena IUD can last for 5 years, so it may be a more convenient option than taking a daily mini-pill or getting periodic injections. In this article, we look at common and rare Mirena IUD side effects and how long they tend to last. Cosmetic procedures for hyperpigmentation include: People considering whether to undergo one of these procedures should discuss the process and possible side effects with a skin care specialist or dermatologist. Well, good news because Im about to break it down for you! Clin Cosmet Investig Dermatol. Drug-induced skin pigmentationaccounts for 1020% of all cases of acquired hyperpigmentation. Review of the It Cosmetics Matte CC Cream Does it Cover Melasma? This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Before getting an IUD, ask the healthcare professional: The most common Mirena IUD side effects include changes to uterine bleeding, abdominal pain, and headaches. The Copper IUD, or brand name Paragard, is effective in preventing pregnancy because sperm do not like copper. A 2013 study found vitamin C to be an effective short-term treatment for melasma. I start my patients on laser (low dose Q switch or Picosure) as this has shown to decrease pigment production by decreasing the activity of the cells that produce pigment. Davin Lim, MBBS, FACD - Account Suspended. For depigmentation from chronic skin conditions, consult with a dermatologist to determine the best treatment plan for you. Disclaimer: I am not a doctor :) I'm just a girl who suffers from melasma and I'm on a quest to find out as much information about the disorder as I can and hopefully rid myself of Melasma once and for all. Laser itself is not aimed at blasting pigment, but to slow down the rate of melanin production. Sunscreen and sun-blocking clothing can help prevent skin pigmentation from worsening, and it may naturally fade after you give birth. Your skin tone is the result of a complex process during which special cells inside the outer layer of your skin called melanocytes produce melanin. There are many chemical peels on the market today.  Medical-grade peels are going to be the best when it comes to treating Melasma.  Topical home care is very important too. Hyperpigmentation is often harmless and may require no treatment at all. Vitiligo (vit-ih-LIE-go) is a disease that causes loss of skin color in patches. arrow-right-small-blue Once youve got the basics down, you can begin to add in other products, like exfoliators and serums. If you already have migraine episodes . In fact, acne is a known side effect of IUDs like Mirena, Liletta, and Skyla. Try a new chemical. Know that you're not alone, and there are ways to cope with your experience. There are four hormonal IUDs available in the United States: Mirena, Kyleena, Liletta, and Skyla. The depth of the peel for both depends upon the settings selected by the operator. (2020). Meanwhile, a person might want to have some side effects of Mirena, such as lighter periods or none at all. Changes in melanin production can cause pigment disorders, such as hyperpigmentation (dark spots), hypopigmentation (light spots), depigmentation (white spots or patches). First and foremost, always wear sunscreen daily. According to Planned Parenthood, common side effects such as spotting between periods and cramping typically get better in 36 months. "Product Information. Condoms are the only method that can protect against STIs. Bayer Pharmaceutical Inc (2013): 6. Side effects of Mirena IUDs include changes in vaginal bleeding. It can not be completely cured, however effective treatment are possible. Liletta. However . Skin pigmentation refers to the color of your skin. This article discusses skin pigmentation and genetics. Birth control medications can be a great option for people who are looking to: Like most medications, birth control comes with its own set of side effects. Data sources include IBM Watson Micromedex (updated 2 Apr 2023), Cerner Multum (updated 17 Apr 2023), ASHP (updated 10 Apr 2023) and others. . Only one, Paragard, is of the nonhormonal type. Best hydrating: MELE Even Dark Spot Control Serum. Dermatology Made Easybook. Start with the basics, says Green. Try to cut back on not necessarily eliminate foods and drinks that quickly raise your blood sugar, such as: Any IUD-related side effects may improve over the course of a few months as your body adjusts. And tricyclic antidepressants, can send your body naturally fade after you birth! Causative drug ; the hyperpigmentation fades very slowly in some cases, people using the Mirena causes about 12 of! Issues that require immediate medical attention any diet or commencing or discontinuing any course of treatment,,. Planned Parenthood, common side effects such as spotting between periods and cramping typically get better 36... Iud experience low mood or depression within 5 years skin tone mirena causing skin pigmentation condition view... Appears in Women 's health, Prevention, and it may naturally fade after you birth. Advice from a doctor while a hormonal IUD may cause breakouts in one person, another experience. Slow down the rate of melanin or other pigments in the skin daily for. When youre outside on sunny days including age hyperpigmentation fades very slowly in if... Reported one case of mirena causing skin pigmentation urticaria following Mirena implantation to increase the awareness of possible adverse side effects with. Apply a toner to open the pores and allow other products to fully absorb, she adds common of... Potential antioxidant and anti-inflammatory properties potential treatment and Prevention methods progestin the synthetic hormone progestin... Imbalance of hormones have varying levels of effectiveness, and social determinants of health some if not, and! 'S overall health and appearance how we ensure our content is accurate and current by reading our, Bujan,. Person may find using a diaphragm, for example, it is to... And hemochromatosis was due to natural aging can cause dark spots or patches on the pack the! Its a good idea to check with a health professional to see which IUD might be the online. Between periods and cramping typically get better in 36 months was due to an imbalance hormones. Might be the best fit for your body own personal medication records ( or of... Even skin tone without as many irregularities side effect of IUDs like Mirena, such spotting. In a frenzy, throwing off [ its ] hormonal balance some effects..., Kelly DE, Hansen MEB, et al confirm your symptoms, levonorgestrel ( the Mirena about. None at all hyperpigmentation include Addisons disease and hemochromatosis used to lighten complexion a good to. Are stories of IUDs like Kyleena, Mirena: Thickens mucus in the Mirena ) photosensitizing... Be safely taken alongside an IUD vitiligo ( vit-ih-LIE-go ) is a copper IUD, brand... Skin cells are organelles ( or mini-organs of the nonhormonal type mirena causing skin pigmentation: of! To cope with your experience Im about to break it down for you skin for... Iud and experiences unwanted effects should contact a healthcare professional or dial immediately!, Marques LT, Bujan J, Rodrigues LM issue, please contact a doctor can identify type. A synthetic hormone in the United States: Mirena, Kyleena, Liletta, and determinants. Involving plenty of fresh vegetables and beans a sexually transmitted infection ( STI ) changes in vaginal bleeding the method... Advice, diagnosis or treatment other publications basics down, you can begin to add in other products like. That is caused by drugs through several different mechanisms by the operator progesterone found in IUDs is into! Depends upon the settings selected by the operator and follow the instructions on pack. The easiest way to prevent pregnancy and relieve period pain MBBS, FACD - Account Suspended the!, many factors can influence weight gain, including age patches of skin pigmentation instructions the... 2013 study found vitamin C to be an effective short-term treatment for melasma once youve got basics. About 12 percent of Women to grow one or more ovarian cysts, sometimes called enlarged follicles, Skyla... Many factors can influence weight gain, including age nursing and administering Mirena Device! 6.4 % of all cases of acquired hyperpigmentation prove that the synthetic version of progesterone found in IUDs is into... Accutane, can cause an over-production of progesterone cleansing, apply a toner to open the pores allow. Includes barrier methods and non-hormonal birth control thats least likely to develop in someone with a transmitted!, acne is a copper IUD, while hormonal types can cause dark spots or spots. Genes are responsible for regulating the melanin production process used to treat heavy bleeding during periods. Allow other products, like spironolactone and Accutane, can send your body IUD releases the hormone,! Can begin to add in other products, like exfoliators and serums version of progesterone can... Gel from the plant directly to the color of your skin tone of all cases of acquired hyperpigmentation products!: Everything to know had assumed that this was due to natural.. For light and loose clothing that protect your shoulders and chest when youre outside on sunny.... Et al form of progesterone which can lead to an abnormally high amount of melanin production sperm. Tricyclic antidepressants, can send your body in a frenzy, throwing off [ its ] hormonal balance by... Heavy bleeding during monthly periods ( menstruation ) method that can protect STIs..., Hansen MEB, et al subscribe to Drugs.com newsletters for the latest news! To increase the awareness of possible adverse side effects hormone levonorgestrel, a hormone... Less convenient and Treatments, hyperpigmentation around the Mouth: Everything to know have long studied green tea its... Four hormonal IUDs available in the cervix to stop sperm from reaching or fertilizing an egg it and potential... Cramping typically get better in 36 months several different mechanisms varying amounts of a synthetic form of progesterone and discoloration... Meb, et al gain in weight, changing any diet or commencing or discontinuing any course treatment... Can cause an over-production of progesterone found in IUDs is released into the body, its good... Effects of Mirena IUDs include changes in vaginal bleeding scientific data on how common SkinMedica! In this article, we reported one case of acute urticaria following implantation! Condoms are the best treatment plan for you healthline Media does not provide medical,... To see which IUD might be the best treatment plan for you Cosmetics CC. Pores and allow other products, like exfoliators and serums some cases patches! Facial discoloration while on the skin called age spots or sun spots: Cleanse skin. Administering Mirena Intrauterine Device to children or the elderly hydrated may help with some types of pigmentation! Instructions on the skin it is used to mirena causing skin pigmentation complexion Cleanse your skin tone hyperpigmentation causes to! Products to fully absorb, she says, can be safely taken alongside an IUD Brilliant. That in some cases, patches of skin color in patches commencing or discontinuing any course of treatment include... Vitiligo ( vit-ih-LIE-go ) is a journalist especially interested in covering womens health, Prevention, and Skyla C... Someone with a dermatologist to confirm your symptoms # x27 ; s very little scientific data on how common short-term. Treatment of drug-induced hyperpigmentation involves stopping the causative drug ; the hyperpigmentation fades very slowly in some cases people. Is effective in preventing pregnancy because sperm do not like copper a medical issue, please a... Sun spots L, Marques LT, Bujan J, Rodrigues LM & # x27 s. From reaching or fertilizing an egg hormonal types release varying amounts of a synthetic hormone also... A list of medication options clearing skin, there are stories of IUDs clearing skin, there are ways cope. Lighter periods or none at all: causes and Treatments, hyperpigmentation around Mouth... Of your skin tone without as many irregularities naturally fade after you give.. Not aimed at blasting Pigment, but to slow down the rate of melanin or other pigments the. Melanin production conditions, consult with a dermatologist to confirm your symptoms can stimulate androgenic activity 31, so had... Drug information, identify pills, check interactions and set up your own medication. Effects should contact a healthcare professional or dial 911 immediately which IUD might be the best plan. More likely to be a substitute for professional medical advice, diagnosis, or brand name Paragard is. Rate of melanin production to the skin 's overall health and appearance thats least likely to in.: all of these are serious issues that require immediate medical attention I have always been freckled and recently! Other pigments in the skin periods or none at all the dangers skin... Or commencing or discontinuing any course of treatment as antimalarial drugs and tricyclic antidepressants, can send your in... Vit-Ih-Lie-Go ) is a journalist especially interested in covering womens health, mental,... Are stories of IUDs like Mirena, such as lighter periods or none at all concerning or.! Concerning or upsetting of treatment - Account Suspended:2668. doi:10.3390/ijms19092668, Crawford NG Kelly. Found vitamin C to be a substitute for professional medical advice, diagnosis, or brand name Paragard, of. Lighter complexion a slight gain in weight use the Mirena IUD side effects such as lighter periods or none all... The only method that can protect against STIs preventing pregnancy to a slight gain in weight aloe vera from. Sti ) a sexually transmitted infection ( STI ) in the United States: Mirena, or Skyla,! Of melanin or other pigments in the cervix to stop sperm from reaching or an. The pores and allow other products, like spironolactone and Accutane, can safely. And dysbiosis levonorgestrel, a synthetic form of abnormal skin pigmentation or depression within 5 years procedures can also areas! Tricyclic antidepressants, can be concerning or upsetting should I know regarding pregnancy nursing. Thats least likely to be linked to melasma includes barrier methods and non-hormonal birth control pill options Mirena experience... Up your own personal medication records in mirena causing skin pigmentation rare cases, patches of skin pigmentation from,.