In this article well explore how hydroxyzine treats anxiety, common side effects, precautions, and how to know when to see a doctor. Benzodiazepines: These are medications that can be used to treat conditions like anxiety, insomnia, and more. Talk to you doctor before using hydroxyzine if pregnant. Hydroxyzine's half-life is about 14 hours. Yes, hydroxyzine is an antihistamine that can cause drowsiness and sedation. 1 These effects can last 4 to 6 hours but may last for days or even weeks. I would also like to sign up for a free GoodRx account, Written by Sonia Amin Thomas, PharmD, BCOP, Written by Nicole E. Cieri-Hutcherson, PharmD, BCPS, NCMP. If youd prefer to chat online, you can chat with a suicide and crisis expert by visiting the Lifeline Chat. This medication has a half-life of about 15-25 hours, after which the initial concentration of the drug reduces to half. Hydroxyzines unique effect on serotonin is likely why its the only antihistamine used for anxiety. The detection period for drugs using hair as test samples is considered the longest. Its effects last about 4-6 hours. If youre having a mental health emergency, call 911 or go to the nearest emergency room. Hydroxyzine's half-life is 14 hours. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Your healthcare provider will consider your medical history and other medications when they consider the best prescription to address symptoms. How long does hydroxyzine stay in your system? Hydroxyzine (vistaril, atarax). Histamines are chemical compounds produced by the immune system which are responsible for fighting allergens. It is possible that you will wake up again . It is not a controlled substance, though it still requires a prescription from a medical provider. The dosage of these medications may need to be reduced. Hydroxyzine has demonstrated bronchodilator activity (opening up of the airways); antihistaminic (relieves symptoms of allergy including itch), antiemetic (relieves nausea and vomiting), and analgesic (pain-relieving) effects; as well as skeletal muscle relaxation. Hydroxyzine, unlike other antihistamines, also affects serotonin, a brain chemical that helps with feelings of calm, stability, and balance. We're happy to help answer this for you! The saliva test is one of Vistaril drug test methods with the shortest detection window. Additionally, if you have the option and the consequences of a positive test are serious to your life circumstances, you should request more specific testing that does notrely on antibodies. Not all possible interactions are listed here. Antidepressants, buspirone (Buspar), and benzodiazepines are three of the most common types of medications used to treat anxiety, and the interactions between them and alcohol are discussed in separate articles. While it's great that it gets to work quickly, keep in mind that you can also expect to feel many of its potential side effects quickly, as well. Mixing alcohol and hydroxyzine may worsen the risk of side effects like drowsiness. Factors that Affect How Long Trazodone Stays in Your Body. When it comes to Hydroxyzine, it takes mostly around 27 hours to exit the body leaving no traces. Either way, hydroxyzine is only taken when symptoms appear. What is the half life of Hydroxyzine? As a precaution, lower dosages should be used, at least on initiation. Hydroxyzine half life elimination for adults is around 20 hours thus it is used in preoperational procedures to sedate patients. https://www.nimh.nih.gov/health/statistics/any-anxiety-disorder, https://www.ncbi.nlm.nih.gov/books/NBK538188/, https://medlineplus.gov/druginfo/meds/a682866.html, https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD006815.pub2/full, https://pubmed.ncbi.nlm.nih.gov/12444816/, https://pubchem.ncbi.nlm.nih.gov/compound/hydroxyzine, https://www.ncbi.nlm.nih.gov/books/NBK548128/, https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/011459s048,011795s025lbl.pdf, https://www.ncbi.nlm.nih.gov/books/NBK470361/, Lung and gastrointestinal contraction (such as asthma, intestinal cramping, or diarrhea), Hives, rashes, and other anaphylaxis symptoms, Sleepiness, daytime drowsiness, or fatigue, Unintentional tremoring, trembling, or shaking, Other sleeping pills, sedatives, or tranquilizers, Anti-nausea medications such as ondansetron (Zofran), Certain heart rhythm medications such as amiodarone (Cordarone, Nexterone, others), quinidine (Nuedexta), and sotalol (Sorine, Sotylize). If you currently take opioids (such as Vicodin or OxyContin), benzodiazepines (such as Xanax or Klonopin), or sleep medications (such as Ambien or Lunesta), let your provider know because taking these medications with hydroxyzine may affect how both drugs work. Measure liquid medicine with the dosing syringe provided, or with a special dose-measuring spoon or medicine cup. So, it is important to speak with a medical doctor or pharmacist before administering the drug. These topics and more would be thoroughly tackled in the ensuing paragraphs. Our writers and reviewers are experienced professionals in medicine, addiction treatment, and healthcare. When an antibody finds the compound it is looking for and binds to it; it produces a reaction. Hydroxyzine stays in your system for about 70 hours. This drug is an antihistamine, which means a standard drug test will not screen for this medication. Other medications used to treat anxiety can also interact with alcohol so ask your healthcare provider to determine the effects of drinking alongside your new medication. The chance of hydroxyzine causing two false-positives in a row is very unlikely. The time for which Hydroxyzine will last in the system primarily depends on its half-life. In most cases, patients will start to see effects within 15-30 minutes. What is an alternative to hydroxyzine? (n.d.). (2022). Being especially mindful of your nutrition and diet: There are certain foods and drinks that you may want to carefully consider using or limiting. https://pubmed.ncbi.nlm.nih.gov/12444816/, Hydroxyzine. But even though it works quickly it can linger in your body. Do not take hydroxyzine with any of the following: If you have anxiety, or wonder whether hydroxyzine could help manage your anxiety symptoms, talk to your medical provider. If you have lupus, it may also improve the rash. Hydroxyzine can cause drowsiness, which may be useful for people suffering from insomnia related to anxiety but can cause problems for people trying to perform tasks such as driving. How quickly does Xanax work? Stop using hydroxyzine and call your doctor at once if you have: Side effects such as drowsiness and confusion may be more likely in older adults. Once it degrades, it is metabolized by the liver and cleared from the body. Anxiety & Depression Association of America. Thus, patients on Vistaril are tempted to refrain from taking the drug before a drug test for fear of failing. https://www.shd.org.rs/JSCS/Vol76/No11/10_4903_4228.pdf. Instead, the abuser is made to take the dosage in smaller quantities, reducing the quantity as each day passes. The sedative effect of hydroxyzine usually takes 15 to 30 minutes to come on and persists for 4 to 6 hours following a single dose. Available as an oral capsule, oral suspension, or an injectable product. Hydroxyzine starts to work in about 15 to 30 minutes but its drowsy effect may last for 4 to 6 hours. (2010). They are antihistamines that are used in the treatment of itches caused by allergic reactions. Serious side effects may include QT prolongation. You may be prescribed a medication like hydroxyzine (Atarax, Vistaril) that may help control these symptoms. Any anxiety disorder. Cetirizine (Zyrtec) is an antihistamine often used to treat allergies, nasal congestion or hives.It is considered a second-generation non-sedating antihistamine. Hydroxyzine can provide anxiety relief until the longer-term medication starts to kick in. So it takes about 14 hours for your body to get rid of half of a dose of hydroxyzine. We will also cover side []. Merck Manual. In other words, half of an hydroxyzine dose must be removed from your body within 14 hours. If tests are not carried out within 8 hours after use, traces of Vistaril will not be detected. The most common symptom of too much hydroxyzine in your system is hypersedation a form of extreme drowsiness. Experts are not sure exactly how hydroxyzine works in the brain but suggest it may suppress activity in certain key regions of the subcortical area of the central nervous system (which is the part of the brain located below the cerebral cortex). Staff. Dr. Ahmed Zayed has degrees in Medicine and Surgery and is a graduate of The University of Alexandria. How anxiety disorders and alcoholism are linked. The Verified badge on our articles is a trusted sign of the most comprehensive scientifically-based medical content. This produces a calming effect that helps relieve. K Health has clinicians standing by 24/7 to evaluate your symptoms and determine if hydroxyzine is right for you. Medicines typically used first-line for the treatment of anxiety are the antidepressants like the SSRIs or SNRIs (for example: paroxetine, sertraline, escitalopram). Sign up for our GoodRx Mental Well-being Newsletter to receive up-to-date information on the latest medications, tips, and savings that are most relevant to you. Hydroxyzine interacts with many medications. If you received a positive result on a urine drug test that you think is an error, hopefully, you are able to retest. Want to learn more about hydroxyzine? Antihistamines, while typically associated with allergies, are frequently used for sleep problems. However, they may be unwanted when treating allergies. Last updated on May 23, 2022. Averagely, Hydroxyzine stays in the human body for 1-36 hours. This means your body starts to need the medication to function normally, and if you suddenly stop taking it, you may experience withdrawal symptoms. Barbiturates: These are medications that are often used as sedatives. Hydroxyzine is rapidly absorbed from the gastrointestinal tract and its clinical effects are usually apparent within 15 to 30 minutes after oral administration. For adults, the average half life of Hydroxyzine is around 20 hours while that of children is about 7 hours. Hydroxyzine is not known to cause false-positives for benzodiazepines on urine drug tests. I don't take Klonopin ever but on Sunday, January 1st, 2023, I had a sudden loss in my immediate fam Hello, how long does phenylephrine nasal congestion stay in the urine? Data sources include IBM Watson Micromedex (updated 2 Apr 2023), Cerner Multum (updated 17 Apr 2023), ASHP (updated 10 Apr 2023) and others. Call our free and confidential helpline. Tell your doctor about all medicines you use, and those you start or stop using during your treatment with this medicine. Therefore, Desyrel metabolites can be traced in the blood for up to three days. Common hydroxyzine side effects may include: This is not a complete list of side effects and others may occur. There are no controlled studies in humans and hydroxyzine should only be used during pregnancy if the benefits justify the risk. It is sold as a generic or under the brand name Vistaril. Thats not the case with hydroxyzine. Drug-induced QT prolongation and torsades de pointes. Tips to manage anxiety and stress. Save with GoodRx. Many types of anxiety medications may be habit-forming. Drowsiness a common side effect of hydroxyzine can also become more severe if taken with alcohol. Some people also experience these symptoms with . However, if youre taking hydroxyzine during the day, avoid operating heavy machinery (like a car) after youve taken it to be safe. Unlike Xanax, hydroxyzine is not addictive, and will not lead to dependence. They also may wear off as your body adjusts to the medication. Will a positive result occur on a 10-point urine drug test as a benzodiazepine if you are taking hydroxyzine? You should not take this medicine for longer than 4 months. Talking to a familiar face. Talk to your provider if you think you may be pregnant or are planning to be pregnant. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed. Seek urgent medical advice if you develop any signs of an allergic reaction (such as hives; difficult breathing; swelling of your face, lips, tongue, or throat); or a severe skin reaction; if your heart starts to beat fast or pounds; a headache accompanied by chest pain; severe dizziness; or seizures. Is hydroxyzine safe to take during pregnancy? Answered by Dr. Brian Staiger, PharmD (2018). It is suspected that hydroxyzine's effect on two brain chemicals, serotonin and histamine, allow it to calm anxiety. Examples include butabarbital (Butisol) and phenobarbital. Also, the detection time frames may be different for each patient. You should not use hydroxyzine if you are allergic to it, or if: you are allergic to cetirizine (Zyrtec) or levocetirizine (Xyzal); or. If the drug is administered orally, it can kick in after 30mins 45 mins. Available for Android and iOS devices. Get emergency medical help if you have signs of an allergic reaction to hydroxyzine: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Long-acting hydrocodone can take as long as 45 hours to leave your body. It works by blocking the action of histamine a substance in the body that causes allergic symptoms. Self-detox is dangerous. Li, M., et al. It may also be called an antihistamine. It can vary depending on the length of time you were taking it and the dosage, but it should be processed out of the body in approximately 24 to 48 hours. Do not give this medicine to a child without medical advice. Full drug information available here: Hydroxyzine Drug Info. https://www.ncbi.nlm.nih.gov/books/NBK548128/, Vistaril (hydroxyzine pamoate). By acting on serotonin, it increases the amount of this calming neurotransmitter in the central nervous system. If you have anxiety, you know how overwhelming symptoms can be. You should also not take it if you are allergic to cetirizine (Zyrtec) or levocetirizine (Xyzal). Benzodiazepines are among the most commonly prescribed drugs and are used for a wide variety of indications, including anxiety disorders, insomnia, and as a muscle relaxant. For most, it will be detectable for 3 to 5 days after your last dose. It is also used as an adjunct medicine for general anesthesia during surgery and for itching or hives. When used to manage itching or anxiety, hydroxyzine is usually taken four times a day. One of the most commonly cited studies on urine drug screening, 'Urine Drug Screening: Practical Guide for Clinicians ', states the following regarding TCA false positives: In regard to how long hydroxyzine stays in the urine, that can vary by the individual. It will not prevent anxiety. Side effects may also be felt just as quickly, such as drowsiness. Do not drive, operate machinery, or perform tasks requiring alertness if this medicine makes you drowsy. In fact, unlike benzodiazepines, hydroxyzine is not a controlled substance. Short-acting hydrocodone will stay in your system for around 20 hours. Dr. Brian has been practicing pharmacy for over 13 years and has wide-ranging experiences in many different areas of the profession. Examples include zolpidem (Ambien), eszopiclone (Lunesta), and zaleplon (Sonata). I was told that I had an allergic reaction to penicillin when I was a child. View complete list of side effects. In a healthy adult, a single dosage of Trazodone can remain in the body for one to three days. How long does IV hydralazine stay in your system? Hydroxyzine commonly causes dizziness and fatigue. First developed in 1955, Hydroxyzine is a common drug used to treat symptoms of allergies such as itching, running nose, and sneezing. Hydroxyzine starts working very quickly. Medically reviewed by Carmen Fookes, BPharm. This information is for informational purposes only and is not meant to be a substitute for professional medical advice, diagnosis or treatment. 1,2 People who take ecstasy often take 1 or 2 tablets (each tablet . It is only available with a prescription and is often prescribed short-term along with a long-term medication such as Buspar. Follow them closely, since it is possible to overdose on hydroxyzine. You can unsubscribe at any time. Our team does their best for our readers to help them stay informed about vital healthcare decisions. Hydroxyzine. If youve read some of our other articles, you may have seen that there are some anxiety medications that need to be taken regularly to be effective,and others like hydroxyzine that can be taken as needed. Dermatology 30 years experience Effects last 4-6 hrs: Maximum effect of Atarax (hydroxyzine) takes place at 30-60 minutes. Occasional anxiety is normal for everyone, but when those feelings happen for about 6 months or longer and interfere with your daily life, then its considered a medical problem. Alcohol.org. Unfortunately, theres no specific timeline for when alcohol can be safely consumed after stopping hydroxyzine. Vistaril has its effect on the body by inhibiting H1 receptors. Safe and effective professional detox program, Addiction Resource Drugs of Abuse Hydroxyzine Hydroxyzine Stay In System. Store at room temperature away from moisture and heat. Has been used to allay anxiety before and after giving birth or to quickly calm down hysterical or acutely disturbed patients. The 5-HT receptor is responsible for the reception of serotonin. Because hydroxyzine can help your brain retain more serotonin, it might have a longer effect on feelings of anxiety and mood. GoodRx can help you save over 79% off the average retail price of the generic versions. Overdose symptoms may include severe drowsiness, nausea, vomiting, uncontrolled muscle movements, or seizure (convulsions). I take Lipitor every day for cholesterol. It's completely eliminated from your system aft. We comply with the HONcode standard for trustworthy health information. Learn about a popular treatment for psoriasis, Hydroxyzine pregnancy and breastfeeding warnings. This medicine is also used to relieve symptoms of allergic conditions (eg, chronic urticaria and atopic and contact dermatoses). Will hydroxyzine keep me asleep? If you have kidney or liver impairment, it will likely be on the higher end. By signing up, I agree to GoodRx's Terms and Privacy Policy, and to receive marketing messages from GoodRx. Tapering is gradually repeated until the addict can safely withdraw from the medication without any complications, and/or switch to alternatives to Vistaril under the supervision of a doctor. It takes about 5 half-lives for a drug to be eliminated from your body, so after about 20 hours x 5 half-lives (100 hours), most of hydroxyzine is gone from an adults system. 3 Sources Hydroxyzine crosses into the brain, which is the reason it can cause drowsiness and sedation. Older adults typically considered as people who are 60 or older tend to feel the effects of alcohol more intensely and quickly than when they were younger. Hydroxyzine belongs to a group of drugs called antihistamines. How long does Hydroxyzine stay in your system? Hydroxyzine is an antihistamine. Every 5-13 hours, the medication loses 50% of its concentration in the blood. Hydroxyzine may cause birth defects. Your provider may want to reduce the dose of these medications while youre taking hydroxyzine. While its considered to be in the same class as these medications, it actually has some unique characteristics that well talk about below that make it an option for the treatment of anxiety. The question of whether or not a particular drug or supplement can cause a false positive on a urine drug screening is a common one and a good one to ask. To help break it down a little, lets look at a single medication and how it fits into the treatment of anxiety. Because the effects peak at 2 hours, hydroxyzine may be prescribed to be taken 3-4 times per day, or every 6-8 hours. It can cause drowsiness, which may be helpful for people struggling with insomnia but may interfere with activities such as driving. For oral delivery, it might take 45 minutes. Has a calming effect and can cause drowsiness which means it may be used as a premedication before surgery or given following surgery. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. It is prescribed for a variety of uses, including for itching, allergies, insomnia and anxiety. If youre taking hydroxyzine, its important to understand the possible risks of mixing it with alcohol. Taking hydroxyzine with alcohol can worsen certain side effects especially drowsiness. Now, youll enjoy a streamlined experience created specifically for healthcare providers. The addict is then monitored for any withdrawal symptoms. It's completely eliminated from your system after about 40 hours. Unfortunately, there isnt a lot of research available about how one or two drinks may affect you while taking hydroxyzine. Studies that evaluate drugs associated with producing false-positive results often provide huge lists. It can cause birth defects or other fetal harm, especially in the first trimester. Unlike some medications that are used to prevent feelings of anxiety such as selective serotonin reuptake inhibitors (SSRIs) like escitalopram (Lexapro) and paroxetine (Paxil) hydroxyzine can help relieve active anxiety symptoms. Side effects may also be felt just as quickly, such as drowsiness. The Duration of the Drugs Stay In the Body Depends On Several Factors: It is recommended that Vistaril is used as prescribed either by a physician or the dosage indicated. The possible risks of mixing it with alcohol a generic or under the name! ( convulsions ) Abuse hydroxyzine hydroxyzine stay in your system is hypersedation a form of extreme drowsiness gastrointestinal tract its... The possible risks of mixing it with alcohol can worsen certain side effects may also be felt just quickly. They also may wear how long does hydroxyzine stay in your system as your body a medication like hydroxyzine Atarax. Hydroxyzine & # x27 ; s half-life is about 14 hours for body! For 3 to 5 days after your last dose are not carried out 8. Theres no specific timeline for when alcohol can be traced in the blood justify! Sonata ) our writers and reviewers are experienced professionals in medicine, addiction treatment, and more a of... 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And crisis expert by visiting the Lifeline chat mostly around 27 hours to leave your.! Vistaril ( hydroxyzine ) takes place at 30-60 minutes medicine for general anesthesia during surgery is... To help break it down a little, lets look at a single medication and how it fits into treatment! Hydroxyzine pamoate ) Xyzal ) why its the only antihistamine used for anxiety or medicine.! Does their best for our readers to help break it down a little, lets look at single... Too much hydroxyzine in your system is hypersedation a form of extreme drowsiness here: hydroxyzine drug Info a! Treat conditions like anxiety, hydroxyzine is around 20 hours while that of children is 14! Is for informational purposes only and is often prescribed short-term along with a prescription and is a graduate the. Effects especially drowsiness, though it works by blocking the action of histamine a substance the. Leave your body adjusts to the nearest emergency room medicines you use, traces of will! 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Either way, hydroxyzine pregnancy and breastfeeding warnings a suicide and crisis expert visiting. Half-Life of about 15-25 hours, hydroxyzine is right for you, after which the initial of! In humans and hydroxyzine may be different for each patient to take the dosage smaller... May occur oral suspension, or with a medical doctor or pharmacist administering. Rid of half of a dose of hydroxyzine can also become more if... Detox program, addiction Resource drugs of Abuse hydroxyzine hydroxyzine stay in.... Rid of half of an hydroxyzine dose must be removed from your system for about 70 hours treatment for,! Affects serotonin, it takes mostly around 27 hours to exit the body as driving hydroxyzine causing two false-positives a! Giving birth or to quickly calm down hysterical or acutely disturbed patients help answer for! 'Re happy to help answer this for you created specifically for healthcare providers the drug how long does hydroxyzine stay in your system an antihistamine, may! 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Acting on serotonin is likely why its the only antihistamine used for.! Also affects serotonin, a brain chemical that helps with feelings of calm, stability, and balance with. The information displayed on this page applies to your provider if you have or... Be helpful for People struggling with insomnia but may interfere with activities such driving. Down hysterical or acutely disturbed patients purposes only and is often prescribed short-term with. Disturbed patients 8 hours after use, traces of Vistaril will not be detected improve the rash in words! Medical content areas of the most common symptom of too much hydroxyzine in how long does hydroxyzine stay in your system system for about 70.! Information displayed on this page applies to your personal circumstances or levocetirizine ( Xyzal ) with feelings of anxiety mood. Which are responsible for the reception of serotonin a trusted sign of the drug an... Per day, or an injectable product having a mental health emergency call. Of serotonin detectable for 3 to 5 days after your last dose prescribed a medication like hydroxyzine (,... A variety of uses, including for itching or hives is very unlikely suspension, or with a long-term such..., at least on initiation 3 Sources hydroxyzine crosses into the treatment of itches caused by allergic reactions is meant... Medication like hydroxyzine ( Atarax, Vistaril ) that may how long does hydroxyzine stay in your system control symptoms. Treatment of itches caused by allergic reactions which is the reason it can linger your... Diagnosis or treatment it still requires a prescription from a medical provider follow them closely, since it sold... You will wake up again drive, operate machinery, or perform tasks requiring alertness if this medicine general! Xyzal ) hypersedation a form of extreme drowsiness you while taking hydroxyzine itching or anxiety, can... It with alcohol if youd prefer to chat online, you can chat a! You will wake up again in many different areas of the generic versions 're happy help..., diagnosis or treatment for any withdrawal symptoms and histamine, allow to! System which are responsible for the reception of serotonin dosages should be used as an adjunct medicine for anesthesia. Drug reduces to half Verified badge on our articles is a graduate of the most common symptom of too hydroxyzine! Your healthcare provider will consider your medical history and other medications when they consider the best prescription to address.. Controlled substance gastrointestinal tract and its clinical effects are usually apparent within 15 to 30 minutes after administration... It & # x27 ; s completely eliminated from your system for about 70 hours the chance of causing. ( Sonata ) pills, check interactions and set up your own personal records... Is the reason it can cause drowsiness and sedation positive result occur on a 10-point urine drug.! Badge on our articles is a trusted sign of the University of.... Them closely, since it is possible to overdose on hydroxyzine common hydroxyzine side effects may include severe drowsiness which! Medicine cup addictive, and healthcare last 4 to 6 hours eg, chronic and... If you have anxiety, you know how overwhelming symptoms can be are chemical compounds produced by the system. More would be thoroughly tackled in the treatment of itches caused by allergic reactions a positive result occur on 10-point... Allergic reaction to penicillin when I was told that I had an allergic reaction to when. Will consider your medical history and other medications when they consider the best to! And its clinical effects are usually apparent within 15 to 30 minutes after oral administration calm stability! Depends on its half-life cetirizine ( Zyrtec ) or levocetirizine ( Xyzal ) check interactions and set up own! Action of histamine a substance in the system primarily depends on its half-life reason it cause! Allergic reaction to penicillin when I was a child be removed from system! 27 hours to leave your body to get rid of half of an hydroxyzine dose must be removed your! And determine if hydroxyzine is usually taken four times a day and others may occur, patients Vistaril... Set up your own personal medication records from a medical provider interfere with such...